Carolina Breast Cancer Study


The Carolina Breast Cancer Study (CBCS) is a population-based case control study of women ages 20 to 74, conducted in 44 counties in North Carolina in the United States. The study began in 1993 and data collection is ongoing. Breast cancer cases are identified using Rapid Case Ascertainment in cooperation with the NC Central Cancer Registry. Controls were identified using Division of Motor Vehicles lists (for women under age 65) and Health Care Financing Administration lists (for women 65 and older). The age range of study participants is 20 to 74. Procedures for recruiting and enrolling study participants were approved by the Institutional Review Board of the UNC School of Medicine and informed consent was obtained for each participant. Cases of invasive breast cancer in the CBCS were enrolled in three phases (Phase 1: 1993-1996, Phase 2: 1996-2001, Phase 3: 2008-2011). Cases of in-situ breast cancer were enrolled during Phase 2 only and all cases of in-situ breast cancer were eligible, with no over-sampling according to age or race.  Controls were enrolled between 1993 and 2001, and were matched to cases based upon age (+/- 5 years) and race.   Phase 3 ascertainment (2008-2011) includes invasive breast cancer cases only. In-depth interviews are conducted in participants' homes by study nurses to obtain information on family history and other risk factors for breast cancer, including reproductive history, physical activity, breast cancer screening and access to health care and other lifestyle factors.  Measurements are taken at the time of interview on height, weight and waist circumference.  Blood samples and/or mouth rinse samples are obtained at the time of interview. 
The total number of participants in the CBCS during Phase 1 and 2 is 4333, with 1803 cases (787 AA, 1016 EA) and 1564 controls (718 AAs, 846 EAs) enrolled in the invasive study, and a total of 508 cases (107 AAs, 401 EAs) and 458 controls (70 AAs, 388 EAs) enrolled in thein-situ study.   Combining the invasive and CIS studies, the contact rates (contacted/eligible) were 98% among cases and 83% among controls; cooperation rates (enrolled / contacted) were 79% for cases and 71% for controls. Thus, DNA samples were obtained from 100% of currently enrolled study participants. 

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